Study participant Sean O’Connell is given a shot in this undated handout photo. Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19. Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection. THE CANADIAN PRESS/HO - University Health Network

Study participant Sean O’Connell is given a shot in this undated handout photo. Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19. Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection. THE CANADIAN PRESS/HO - University Health Network

Canadian researchers explore whether TB vaccine offers COVID-19 protection

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure

Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19.

Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection.

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure, with researchers hoping to recruit more than 3,600 participants.

Principal co-investigator Dr. Alexandre Zlotta says that if the inexpensive vaccine proves helpful, it can be rapidly deployed to offer temporary protection until a COVID-specific vaccine is widely available.

While BCG continues to be used in European and developing countries, Canada discontinued routine use in the early 1970s, according to Toronto Public Health.

Tuberculosis cases in Canada are among the lowest in the world, although certain vulnerable populations are at higher risk for the infectious, bacterial disease.

Dubbed “COBRA,” the double-blind placebo-controlled study is unfolding alongside trials in Germany and the United States. Experts expect to release results in May 2021.

Interest in BCG emerged early in the pandemic when researchers noticed some countries with higher rates of BCG coverage also had significantly lower rates of COVID-19 deaths. But more recent analysis reflecting the pandemic’s movement across the globe bucks that idea.

“Lack of evidence for BCG vaccine protection from severe COVID-19,” states the headline of a letter published in the Proceedings of the National Academy of Sciences on Sept. 29.

Citing updated analysis based on data from the Johns Hopkins University Coronavirus Resource Center, the study notes Bolivia, Panama, Columbia, Peru, Brazil, Mexico and South Africa had the largest increases in COVID-19 deaths on Aug. 1, even though the countries also have high BCG coverage.

The letter concludes by saying ongoing randomized controlled trials should provide more concrete answers.

UHN says the Canadian study uses an improved version of the vaccine, which researchers expect “will help muster a stronger immune response.”

“The big advantage here is this vaccine has been given to billions of people around the world in the past decades,” Zlotta says in a release.

“It is safe and readily available. If the study is successful, this could become an important strategy to control the secondary waves of the pandemic.”

The study is being funded by The Princess Margaret Cancer Foundation.

Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Just Posted

Students at Creston Valley Secondary School put together an art installation of a replica residential school room. (Photo by Kelsey Yates)
Creston students create art installation of residential school room

The replica was decorated with a small bed, school uniform, and notes written with pleas for help

A living wage sets a higher standard than the minimum wage; it is what a family needs to earn to provide the basic needs based on the actual costs of living in a community.
Fruitvale now a living wage employer

“I’m really excited that Fruitvale is leading the charge for municipalities locally,” Morissette said.

Nelson police say a man attacked two people downtown with bear spray on Wednesday afternoon. File photo
Two people attacked with bear spray in downtown Nelson: police

Police say the three people know each other

Rotary eClub of Waneta Sunshine, alongside members from the Kootenay Native Plant Society and Trail Wildlife Association, joined together for a day of planting at Fort Shepherd. The Waneta Sunshine eClub was granted funds through an Express Grant from District 5080 to plant 50 shrubs which support pollinator opportunities at Fort Shepherd. Photos: Submitted
Kootenay conservation partners plant pollinator ‘superfoods’ at Fort Shepherd

TLC welcomes community groups to Fort Shepherd who would like to help local ecosystems thrive

Harold and Sadie Holoboff are bringing great food and service to the Eagle’s Nest Restaurant at Champion Lakes Golf and Country Club. Photo: Jim Bailey
West Kootenay golf course welcomes father-daughter team to restaurant

Chef Harold Holoboff brings comfort food to another level at Champion Lakes Eagle’s Nest Restaurant

People line up to get their COVID-19 vaccine at a vaccination centre, Thursday, June 10, 2021 in Montreal. THE CANADIAN PRESS/Ryan Remiorz
Vaccines, low COVID case counts increase Father’s Day hope, but risk is still there

Expert says people will have to do their own risk calculus before popping in on Papa

FILE – A science class at L.A. Matheson Secondary in Surrey, B.C. on March 12, 2021. (Lauren Collins/Surrey Now Leader)
Teachers’ union wants more COVID transmission data as B.C. prepares for back-to-school

BCTF says that details will be important as province works on plan for September

Provincial health officer Dr. Bonnie Henry outlines B.C.’s COVID-19 restart plan, May 25, 2021, including larger gatherings and a possible easing of mandatory masks on July 1. (B.C. government photo)
B.C. records 120 new COVID-19 cases, second vaccines accelerating

Lower Pfizer deliveries for early July, Moderna shipments up

A Heffley Creek peacock caught not one - but two - lifts on a logging truck this month. (Photo submitted)
Heffley Creek-area peacock hops logging trucks in search of love

Peacock hitched two lifts in the past month

The Calgary skyline is seen on Friday, Sept. 15, 2017. THE CANADIAN PRESS/Jeff McIntosh
2 deaths from COVID-19 Delta variant in Alberta, 1 patient was fully immunized

Kerry Williamson with Alberta Health Services says the patients likely acquired the virus in the hospital

The first suspension bridge is the tallest in Canada, with a second suspension bridge just below it. The two are connected by a trail that’s just over 1 km. (Claire Palmer photo)
PHOTOS: The highest suspension bridges in Canada just opened in B.C.

The Skybridge in Golden allows visitors to take in views standing at 130 and 80 metres

BC Green Party leader and Cowichan Valley MLA Sonia Furstenau introduced a petition to the provincial legislature on Thursday calling for the end of old-growth logging in the province. (File photo)
BC Green leader Furstenau introduces old-growth logging petition

Party calls for the end of old-growth logging as protests in Fairy Creek continue

B.C. Premier John Horgan leaves his office for a news conference in the legislature rose garden, June 3, 2020. (B.C. government photo)
B.C. premier roasted for office budget, taxing COVID-19 benefits

Youth addiction law that triggered election hasn’t appeared

A vial containing the Moderna COVID-19 vaccine is shown at a vaccination site in Marcq en Baroeul, outside Lille, northern France, Saturday, March 20, 2021. THE CANADIAN PRESS/AP/Michel Spingler
mRNA vaccines ‘preferred’ for all Canadians, including as 2nd dose after AstraZeneca: NACI

New recommendations prioritizes Pfizer, Moderna in almost all cases

Most Read